TRANSLATIONAL PHYSIOLOGY Therapeutic potential of sustained-release sodium nitrite for critical limb ischemia in the setting of metabolic syndrome
نویسندگان
چکیده
David J. Polhemus,* Jessica M. Bradley,* Kazi N. Islam, Luke P. Brewster, John W. Calvert, Ya-Xiong Tao, Carlos C. Chang, Iraklis I. Pipinos, Traci T. Goodchild, and David J. Lefer Cardiovascular Center of Excellence and Department of Pharmacology, LSU Health Sciences Center, New Orleans, Louisiana; Department of Surgery, Emory University School of Medicine, Atlanta, Georgia; Surgery and Research Services, Atlanta Veterans Affairs Medical Center, Decatur, Georgia; Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia; Department of Anatomy, Physiology, and Pharmacology, Auburn University College of Veterinary Medicine, Auburn, Alabama; T3 Labs, Emory University, Atlanta, Georgia; and Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska
منابع مشابه
Therapeutic potential of sustained-release sodium nitrite for critical limb ischemia in the setting of metabolic syndrome.
Nitrite is a storage reservoir of nitric oxide that is readily reduced to nitric oxide under pathological conditions. Previous studies have demonstrated that nitrite levels are significantly reduced in cardiovascular disease states, including peripheral vascular disease. We investigated the cytoprotective and proangiogenic actions of a novel, sustained-release formulation of nitrite (SR-nitrite...
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Metabolic syndrome (MetS) reduces endothelial nitric oxide (NO) bioavailability and exacerbates vascular dysfunction in patients with preexisting vascular diseases. Nitrite, a storage form of NO, can mediate vascular function during pathological conditions when endogenous NO is reduced. The aims of the present study were to characterize the effects of severe MetS and obesity on dyslipidemia, my...
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